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The Organic Chemistry of Drug Design and Drug Action, Third Edition, by Richard B. Silverman Ph.D Organic Chemistry, Mark W. Holladay
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The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows the reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition reflects significant changes in the process of drug design over the last decade. It preserves the successful approach of the previous editions while including significant changes in format and coverage.
- Updates to all chapters, including new examples and references
- Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book
- Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry
- Chapter 3 (Receptors): Drug-receptor interactions, cation-π and halogen bonding; atropisomers; case history of the insomnia drug suvorexant
- Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis
- Chapter 5 (Enzyme Inhibition and Inactivation): New case histories:
- for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib
- for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid
- for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin
- Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples
- Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites
- Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates
- Sales Rank: #229515 in Books
- Published on: 2014-06-10
- Original language: English
- Number of items: 1
- Dimensions: 11.15" h x 1.20" w x 8.71" l, 3.81 pounds
- Binding: Hardcover
- 536 pages
Most helpful customer reviews
0 of 0 people found the following review helpful.
wonderful book the concepts are explained easy and clear for ...
By afeisha carter
wonderful book the concepts are explained easy and clear for you to understand Even if chemistry isn't your best subject. Love the examples at the end of the chapter to test your understanding. the author is very knowledgeable on drug design.
0 of 0 people found the following review helpful.
Brand new like I expected and it's really good
By H.
Brand new like I expected and it's really good, you just need a professor ti explain some of the examples
0 of 0 people found the following review helpful.
Five Stars
By Michael Hadd
Well thought out and referenced, if you are interested in drug design you should have this book
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